Association of ABCB6 Polymorphisms and Serum Levels with Susceptibility to Antituberculosis Drug-induced Hepatotoxicity

Authors

  • Ruina Chen Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China
  • Jingru Cheng Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China
  • Hongqiu Pan Department of Tuberculosis, The Third People’s Hospital of Zhenjiang Affiliated to Jiangsu University, Zhenjiang, China.
  • Lihuan Lu Department of Tuberculosis, The Second People’s Hospital of Changshu, Changshu, China.
  • Xiaomin He Department of Infectious Disease, The People’s Hospital of Taixing, Taixing, China.
  • Meiling Zhang Department of Infectious Disease, The Jurong Hospital Affiliated to Jiangsu University, Jurong, China.
  • Honggang Yi Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China
  • Shaowen Tang Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China

DOI:

https://doi.org/10.15403/jgld-5892

Keywords:

antituberculosis drug-induced hepatotoxicity, ATP-binding cassette B6, ABCB6, genetic polymorphisms, case − control study

Abstract

Background and Aims: The occurrence of anti-tuberculosis drug-induced hepatotoxicity (ATDH) deserves our attention. To explore the role of ATP-binding cassette B6 (ABCB6) polymorphisms and serum levels in the risk of antituberculosis drug-induced hepatotoxicity (ATDH).

Methods: A 1:4 matched case‒control study was conducted. Four single nucleotide polymorphisms (SNPs) and serum ABCB6 levels were analyzed, and false discovery rate (FDR) was performed to correct for multiple comparison.

Results: 224 ATDH cases and 896 controls were included. SNP rs1109867 in ABCB6 gene had a decreased risk of ATDH under dominant models (FDR corrected p-value = 0.027). Furthermore, serum ABCB6 levels at three different times in the ATDH cases were higher than those in the controls.

Conclusions: SNP rs1109867 in ABCB6 gene may contribute to the susceptibility to ATDH among patients receiving anti-TB treatment.

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Published

2025-03-27

How to Cite

1.
Chen R, Cheng J, Pan H, Lu L, He X, Zhang M, Yi H, Tang S. Association of ABCB6 Polymorphisms and Serum Levels with Susceptibility to Antituberculosis Drug-induced Hepatotoxicity. JGLD [Internet]. 2025 Mar. 27 [cited 2026 May 1];34(1):55-63. Available from: https://jgld.ro/jgld/index.php/jgld/article/view/5892

Issue

Vol. 34 No. 1: March 2025

Section

Original Article