Correlation of Metabolic Risk Factors with Sessile Serrated Lesions

Authors

  • Melania Macarie George Emil Palade University of Medicine, Pharmacy, Science, and Technology, Department of Gastroenterology, Târgu- Mureș, Romania
  • Simona Bataga George Emil Palade University of Medicine, Pharmacy, Science, and Technology, Department of Gastroenterology, Târgu- Mureș, Romania
  • Simona Mocan County Clinical Emergency Hospital, Department of Pathology, Târgu-Mureș, Romania
  • Monica Pantea George Emil Palade University of Medicine, Pharmacy, Science, and Technology, Department of Gastroenterology, Târgu- Mureș, Romania
  • Razvan Opaschi George Emil Palade University of Medicine, Pharmacy, Science, and Technology, Department of Gastroenterology, Târgu- Mureș, Romania
  • Septimiu Voidazan George Emil Palade University of Medicine, Pharmacy, Science, and Technology, Department of Epidemiology, Târgu-Mureș, Romania
  • Ioan Macarie George Emil Palade University of Medicine, Pharmacy, Science, and Technology, Department of Internal Medicine, Târgu- Mureș, Romania

DOI:

https://doi.org/10.15403/jgld-507

Keywords:

colorectal polyps, obesity, sessile serrated, epidemiology

Abstract

Background and Aims: The importance of sessile serrated lesions (SSLs) in the pathogenesis of colorectal carcinoma has been recently established. These are supposed to cause the so-called “interval cancer”, having a rapidly progressive growth and being difficult to detect and to obtain an endoscopic complete resection. We aimed to establish the most important metabolic risk factors for sessile serrated lesions.

Methods: We performed a retrospective case-control study, on a series of 2918 consecutive patients who underwent colonoscopy in Gastroenterology and Endoscopy Unit, County Clinical Emergency Hospital, Târgu-Mureș, Romania between 1 st of January 2015-31 th of December 2017. In order to evaluate the metabolic risk factors for polyps’ development, enrolled participants were stratified in two groups, a study group, 33 patients with SSLs lesions, and a control group, 138 patients with adenomatous polyps, selected by systematic sampling for age and anatomical site. Independent variables investigated were: gender, smoking, alcohol consumption, obesity, arterial hypertension, diabetes, hypercholesterolemia, hypertriglyceridemia, hyperuricemia, nonalcoholic liver disease.

Results: For SSLs the most common encountered localization was the right colon in 30.55% of cases. By comparative bivariate analysis between SSLs group and control group, it was observed that hypertension (p=0.03, OR 2.33, 95 %CI 1.03-5.24), obesity (p=0.03, OR 2.61, 95 %CI 1.08-6.30), hyperuricemia (p=0.04, OR 2.72, 95 %CI 1.28-7.55), high cholesterol (p=0.002, OR 3.42; 95 %CI 1.48-7.87), and high triglycerides level (p=0.0006, OR 5.75; 95 %CI 1.92-17.2) were statistically associated with SSLs development. By multivariate analysis hypertension and hypertriglyceridemia retained statistical significance.

Conclusions: Our study showed that the highest prevalence of SSLs was in the right colon and hypertension and increased triglycerides levels were associated with the risk of SSLs development. These risk factors are easy to detect in clinical practice and may help identifying groups with high risk for colorectal cancer, where screening is recommended.

Downloads

Published

2020-06-03

How to Cite

1.
Macarie M, Bataga S, Mocan S, Pantea M, Opaschi R, Voidazan S, Macarie I. Correlation of Metabolic Risk Factors with Sessile Serrated Lesions. JGLD [Internet]. 2020 Jun. 3 [cited 2025 Jul. 16];29(2):175-9. Available from: https://jgld.ro/jgld/index.php/jgld/article/view/507

Issue

Section

Original Article