The Gut Microbiota Profile in Heart Failure Patients: A Systematic Review

Authors

  • Daniel Martin Simadibrata Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Nuffield Department of Population Health (NDPH), University of Oxford, Oxford, United Kingdom https://orcid.org/0000-0002-7512-2112
  • Salwa Auliani Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia
  • Putu Ayu Widyastuti Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia
  • Alya Darin Wijaya Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia
  • Hilman Zulkifli Amin Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan
  • Hary Sakti Muliawan Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia
  • Bambang Budi Siswanto Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia
  • Marcellus Simadibrata Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Ciptomangunkusumo Hospital, Jakarta, Indonesia

DOI:

https://doi.org/10.15403/jgld-4779

Keywords:

SCFA, Firmicutes, short-chain fatty acid, gut microbiota, dysbiosis, heart failure

Abstract

Background and Aims: Traditional cardiovascular risk factors are established predictors of heart failure (HF). However, the human gut microbiota is suggested to potentially interact with the cardiovascular system through the “gut-heart axis”, which induces inflammation and contributes to HF pathogenesis. This systematic review aims to confirm the interconnection between the gut microbiome in HF patients.

Methods: Peer-reviewed human studies comparing the gut microbiota profile in adult patients with HF and healthy controls (HCs) up to April 18, 2022, were searched in Ovid MEDLINE, Ovid EMBASE, SCOPUS, and the Cochrane Library. The quality of the included studies was assessed using the Newcastle-Ottawa Scale (NOS).

Results: A total of nine studies, including 317 HF patients and 510 HCs, were included in the review. Decreased gut microbiota richness and similar microbial diversity (alpha diversity), and significantly different gut microbiota composition (beta diversity) were observed between HF patients and HCs. In comparison to HCs, HF patients had a greater abundance of Actinobacteria, Proteobacteria, and Synergistetes phyla; Enterococcus, Escherichia, Klebsiella, Lactobacillus, Streptococcus, and Veilonella genera and Ruminococcus gnavus, Streptococcus sp., and Veilonella sp. species. In contrast, there was decreased abundance of Firmicutes phylum; Blautia, Eubacterium, Faecalibacterium, and Lachnospiraceae FCS020 genera; and Dorea longicatena, Eubacterium rectale, Faecalibacterium prausnitzii, Oscillibacter sp., and Sutterella wadsworthensis species in HF patients.

Conclusions: Gut microbiota diversity, richness, and composition in HF patients differ significantly from the healthy population. Overall, short-chain fatty acid (SCFA)-producing gut microbiota was depleted in HF patients. However, different underlying comorbidities, environments, lifestyles, and dietary choices could affect gut microbiota heterogeneity.

Published

2023-09-29

How to Cite

1.
Simadibrata DM, Auliani S, Widyastuti PA, Wijaya AD, Amin HZ, Muliawan HS, Siswanto BB, Simadibrata M. The Gut Microbiota Profile in Heart Failure Patients: A Systematic Review. JGLD [Internet]. 2023 Sep. 29 [cited 2025 Jul. 14];32(3):393-401. Available from: https://jgld.ro/jgld/index.php/jgld/article/view/4779

Issue

Section

Systematic Review