Contrast-Enhanced Ultrasound and Computed Tomography Assessment of Hepatocellular Carcinoma after Transcatheter Arterial Chemo-Embolization: A Systematic Review

Authors

  • Cheng-Jeng Tai Division of Hematology and Oncology, Department of Internal Medicine; School of Medicine, College of Medicine,Taipei, Taiwan
  • Ming-Te Huang Department of Surgery, School of Medicine, College of Medicine, Taipei, Taiwan
  • Chih-Hsiung Wu Department of Surgery, Taipei Medical University-Shuang Ho Hospital, Taipei, Taiwan
  • Chen-Jei Tai Department of Chinese Medicine; Traditional Herbal Medicine Research Center, Taipei, Taiwan
  • Yeu-Ching Shi Taiwan Indigena Botanica Co., Ltd., Taipei, Taiwan; Division of Gastroenterology, Department of Internal Medicine, Taipei, Taiwan
  • Chun-Chao Chang Division of Gastroenterology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan
  • Yu-Jia Chang Division of General Surgery, Department of Surgery, Taipei Medical University Hospital; Graduate Institute of Clinical Medicine, College of Medicine, Taipei, Taiwan
  • Li-Jen Kuo Department of Surgery, School of Medicine, College of Medicine, Taipei, Taiwan; Division of General Surgery, Department of Surgery, Taipei Medical University Hospital; Graduate Institute of Clinical Medicine, College of Medicine, Taipei, Taiwan
  • Po-Lei Wei Department of Surgery, School of Medicine, College of Medicine, Taipei, Taiwan; Division of General Surgery, Department of Surgery, Taipei Medical University Hospital; Graduate Institute of Clinical Medicine, College of Medicine, Taipei, Taiwan
  • Ray-Jade Chen Department of Surgery, School of Medicine, College of Medicine ; Division of General Surgery, Department of Surgery, Taipei Medical University Hospital; Taipei, Taiwan
  • Hung-Yi Chiou School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan

DOI:

https://doi.org/10.15403/jgld.2014.1121.254.tai

Keywords:

hepatocellular carcinoma, transarterial chemoembolization, contrast-enhanced ultrasound, contrast enhanced CT

Abstract

Background & Aims: Contrast-enhanced ultrasound (CEUS) and contrast-enhanced computed tomography (CECT) are used to assess the response of hepatocellular carcinoma after transarterial chemoembolization. Our aim was to perform a systematic review to compare CEUS and CECT for therapeutic response assessment to transarterial chemoembolization in the treatment of hepatocellular carcinoma.

Method: PubMed, Embase, and the Cochrane Library databases were searched from inception until January 1, 2016. Participants: patients with hepatocellular carcinoma. Intervention: transarterial chemoembolization and CECT vs CEUS.

Results. Sixteen studies were included in the systematic review. The total number of patients was 858 and the mean patient age ranged from 42 to 73 years. The mean tumor size ranged from 1.0 cm to 4.3 cm. The sensitivity and specificity of CEUS ranged from 46% to 100% and 65% to 100%, respectively, and that of CECT ranged from 34% to 87% and 92% to 100%, respectively. The accuracy of CEUS ranged from 72.6% to 100% and that of CECT from 61% to 94%. Marked heterogeneity was present among the studies.

Conclusion: CEUS is comparable with CECT for the therapeutic response assessment after transarterial chemoembolization.

Abbreviations: CECT: Contrast-enhanced CT; CEUS: Contrast-enhanced Ultrasound; CT: Computed Tomography; HCC: Hepatocellular Carcinoma; MDCT: Multidetector row CT; MRI: Magnetic Resonance Imaging; mRECIST: modified Response Evaluation Criteria in Solid Tumors; NPV: Negative Predictive Value; PPV: Positive Predictive Value; QUADAS-2: Quality Assessment of Diagnostic Accuracy Studies; RFA: Radiofrequency Ablation; TACE: Transcatheter Arterial Chemoembolization.

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Published

2016-12-01

How to Cite

1.
Tai C-J, Huang M-T, Wu C-H, Tai C-J, Shi Y-C, Chang C-C, Chang Y-J, Kuo L-J, Wei P-L, Chen R-J, Chiou H-Y. Contrast-Enhanced Ultrasound and Computed Tomography Assessment of Hepatocellular Carcinoma after Transcatheter Arterial Chemo-Embolization: A Systematic Review. JGLD [Internet]. 2016 Dec. 1 [cited 2026 Jun. 6];25(4):499-507. Available from: https://jgld.ro/jgld/index.php/jgld/article/view/1036

Issue

Vol. 25 No. 4: December 2016

Section

Systematic Review