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Affiliations
Mircea Manuc
Gastroenterology and Hepatology Dept., Fundeni Clinical Institute, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Carmen M. Preda
Gastroenterology and Hepatology Dept., Fundeni Clinical Institute, Carol Davila University of Medicine and Pharmacy, Bucharest
Corneliu P. Popescu
Internal Medicine Dept., Colentina Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Cristian Baicuș
Internal Medicine Dept., Colentina Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Theodor Voiosu
Internal Medicine Dept., Colentina Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Corina S. Pop
Gastroenterology Dept., Emergency Universitary Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Liana Gheorghe
Gastroenterology and Hepatology Dept., Fundeni Clinical Institute, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Ioan Sporea
Gastroenterology and Hepatology Dept., Timisoara Emergency Hospital, University of Medicine and Pharmacy, Timișoara, Romania
Anca Trifan
Gastroenterology and Hepatology Dept., Gastroenterology and Hepatology Institute, Gr. T. Popa University of Medicine and Pharmacy, Iași, Romania
Marcel Tanțău
Regional Institute of Gastroenterology and Hepatology, and Iuliu Hațieganu University of Medicine and Pharmacy, Cluj- Napoca, Romania
Alina Tanțău
4th Medical Clinic, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj- Napoca, Romania
Emanoil Ceaușu
Virology Dept., Victor Babes Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Doina Proca
Gastroenterology and Hepatology Dept., Fundeni Clinical Institute, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Ileana Constantinescu
Gastroenterology and Hepatology Dept., Fundeni Clinical Institute, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Simona M. Ruta
Virology Dept., Victor Babes Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Larisa E. Fulger
Gastroenterology and Hepatology Dept., Fundeni Clinical Institute, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Mircea Diculescu
Gastroenterology and Hepatology Dept., Fundeni Clinical Institute, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Alexandru Oproiu
Dept. Gastroenter, Agrippa Ionescu Hospital, Bucharest, Romania
How to Cite
New Epidemiologic Data Regarding Hepatitis C Virus Infection in Romania
- Mircea Manuc ,
- Carmen M. Preda ,
- Corneliu P. Popescu ,
- Cristian Baicuș ,
- Theodor Voiosu ,
- Corina S. Pop ,
- Liana Gheorghe ,
- Ioan Sporea ,
- Anca Trifan ,
- Marcel Tanțău ,
- Alina Tanțău ,
- Emanoil Ceaușu ,
- Doina Proca ,
- Ileana Constantinescu ,
- Simona M. Ruta ,
- Larisa E. Fulger ,
- Mircea Diculescu ,
- Alexandru Oproiu
Vol 26 No 4: December 2017
Section: Original Article
Pages: 381-386
Abstract
Background & Aims: Literature data suggest that HCV genotype-1b is present in 93-99% of the Romanian patients infected with hepatitis C virus (HCV). We present the genotyping tests recently performed on patients with HCV and advanced fibrosis eligible for the Direct-Acting Antiviral (DAA) therapy, as well as the prevalence of these cases across Romania.
Methods: The genotyping method was performed on 7,421 HCV patients with advanced fibrosis. The detection method was automatic real time PCR platform M2000 (Abbott). Every subject was introduced into a database including age, sex, county and address.
Results: Genotype 1b was almost exclusively present: 7,392/7,421 (99.6%). Genotype 1b patients were 19.6% from Bucharest, 49% were males, with a median age of 60 years. Genotype non-1b was encountered in 29/7,421 subjects (0.4%), 62% were males, 69% from Bucharest and the median age was 52 years. Most of the subjects (75%) were in the 6th and 7th age decade. The prevalence of these cases varied significantly across Romanian counties: the highest was in Bucharest (61.3/105), Bihor (47/105), Iasi (46/105) and Constanța (43/105), and the lowest in Ilfov (2.8/105), Harghita (3.7/105), Covasna (5.4/105) and Maramureș (8.8/105) (p<0.001).
Conclusions: Genotype 1b is encountered in 99.6% of patients with chronic hepatitis C and advanced fibrosis from Romania. The presence of genotypes non-1b is more common in Bucharest, in males and at a younger age. There are significant differences regarding the distribution of these cases across Romania: the highest rates are in Bucharest, Bihor, Iasi and Constanta.
Abbreviations: BMI: body mass index; DAA: direct-acting antiviral agent; GT: genotype; HBV: hepatitis B virus; HCC: hepatocellular carcinoma; HCV: hepatitis C virus; IDU: intravenous drug users; MELD: model for end stage liver disease; NASH: non-alcoholic steatohepatitis; SVR; sustained virologic response.